Aptos and NEAR Protocol were the only gainers, each rising 1.7%.
Cardano was also among the underperformers, falling 7% since Monday.
Polygon joined Cardano as a top performer, gaining 7.9%.
Solana joins Uniswap as a top performer, gaining 12.7% as U.S. Presidential election results come in.
Hedera was also among the top performers, rising 4.1% from Monday.
Aptos also joined Uniswap as an underperformer, declining 7.6% from Friday.
Render joined Uniswap as a top performer, gaining 2.6%.
Uniswap joined Aptos as an underperformer, declining 3.9%
NEAR Protocol was also among the underperformers, falling 2.8%.
NEAR Protocol also joined Aptos as a top performer, gaining 5.8%.
NEAR Protocol also joined Aptos as an underperformer, falling 2.2% from Thursday.
Bitcoin Cash was also among the top performers, gaining 2.9% since Wednesday.
Internet Computer was the only gainer, rising 2.3% from Tuesday.
Hedera joined Solana as a top performer, rising 5.6% over the weekend.
Only two assets were trading lower, including Aptos and Litecoin.
Uniswap also joined Hedera as an underperformer, falling 3.9%.
Chainlink also underperformed, falling 2.1%.
Uniswap was also a top performer, gaining 2.9%.
LTC was also a top performer, gaining 2.7%
AVAX jumped 12.5% and APT rose 9.9%, leading the gainers.
Index stumbles 2.1% with Polygon leading declines, while Uniswap and Litecoin remain in green.
Litecoin gained 2.4% while Bitcoin Cash rose 2% in overnight trading.
AVAX leads with a 7.4% increase, closely followed by NEAR at 7.3%, lifting the index higher.
UNI falls 5.8% while NEAR loses 2'8% in mixed performance for CoinDesk 20's top assets.
Litecoin gained 2.1% while Internet Computer rose 1.9% in overnight trading.
APT gained 3.9% and BCH rose 2.7%, helping to balance out XRP’s losses.
CoinDesk 20 sees a broad rally, with RNDR up 14.2% and SOL up 8.3%.
The CoinDesk 20 gains 1.2% overnight with BCH up 3.0% and ETC up 2.5%.